Quins centre George Lowe has been ruled out of action for six weeks after undergoing surgery this morning.
The 22-year-old former Epsom College student, who missed Sunday's 18-16 defeat to Saracens, has had a bone fragment removed from his ankkle.
Director of rugby Conor O'Shea has made two changes to the starting line-up of the team that lost last week with Karl Dickson starting ahead of Danny Care and Mark Lambert making his first start of the season at loose head.
Prop Joe Marler has been dropped to the bench.
Quins team to face Exeter Chiefs:
15. Mike Brown, 14. Seb Stegmann, 13. Matt Hopper, 12. Jordan Turner-Hall, 11. Ugo Monye, 10. Nick Evans, 9. Karl Dickson, 1. Mark Lambert, 2. Joe Gray, 3. James Johnston, 4. Olly Kohn, 5. George Robson, 6. Tom Guest, 7. Chris Robshaw ©, 8. Nick Easter.
Replacements: 16. Rob Buchanan, 17. Joe Marler, 18. Will Collier, 19. Charlie Matthews, 20. Maurie Fa’asavalu, 21. Danny Care, 22. Rory Clegg, 23. Ollie Lindsay-Hague.